“The success of bone regeneration hinges on the interplay between biomaterials, stem cells, and vascularization, paving the way for transformative advancements in regenerative medicine.”

Bone regeneration is a critical field of research in orthopaedics and regenerative medicine. Recent studies on de novo bone formation in animal models have provided valuable insights into the biological mechanisms driving bone growth and repair. These models have been instrumental in understanding the role of stem cells, biomaterials, and growth factors in skeletal tissue engineering. One of the key findings in recent research is the importance of angiogenesis—the formation of new blood vessels—in successful bone regeneration. Vascularization plays a crucial role in delivering nutrients and oxygen to the developing bone, ensuring structural integrity and long-term viability. Researchers have also explored the potential of biodegradable scaffolds and gene therapy to enhance bone healing and regeneration in clinical applications. Animal models such as rats, rabbits, and non-human primates have been extensively used to test innovative bone graft substitutes and regenerative strategies. These studies provide a foundation for future human clinical trials, potentially revolutionizing treatments for bone defects and fractures. The ongoing research in this field aims to translate these experimental findings into practical applications, improving patient outcomes and advancing orthopedic medicine.